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Wellness FAQ
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Metformin has been studied for its potential to promote longevity by influencing metabolic and cellular processes associated with aging, such as reducing oxidative stress and improving insulin sensitivity. Some animal studies have shown that metformin may extend lifespan and delay age-related diseases. However, its effectiveness in humans for this purpose is still under investigation. Clinical trials, such as the TAME (Targeting Aging with Metformin) study, aim to determine whether metformin can significantly impact human aging.
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Metformin is believed to influence longevity by targeting several key mechanisms associated with aging. It activates AMPK (adenosine monophosphate-activated protein kinase), a cellular energy regulator that promotes metabolic health, reduces inflammation, and improves insulin sensitivity. Metformin also appears to reduce oxidative stress and inhibit mTOR (mechanistic target of rapamycin), a pathway linked to aging and age-related diseases. These effects may help delay the onset of chronic conditions such as cardiovascular disease, cancer, and neurodegenerative disorders, which are significant contributors to mortality.
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